Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses

Gobert,Geoffrey N., Burke, Melissa L., Mcmanus, Donald P., Ellis, Magda K., Chuah, Candy, Ramm, Grant A., Wang, Yuanyuan and Li, Yuesheng (2015) Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses. Parasitology, 142 12: 1453-1468. doi:10.1017/S0031182015000682


Author Gobert,Geoffrey N.
Burke, Melissa L.
Mcmanus, Donald P.
Ellis, Magda K.
Chuah, Candy
Ramm, Grant A.
Wang, Yuanyuan
Li, Yuesheng
Title Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses
Formatted title
Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses
Journal name Parasitology   Check publisher's open access policy
ISSN 1469-8161
0031-1820
Publication date 2015
Sub-type Article (original research)
DOI 10.1017/S0031182015000682
Open Access Status Not yet assessed
Volume 142
Issue 12
Start page 1453
End page 1468
Total pages 16
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2016
Language eng
Formatted abstract
Schistosomiasis is a significant cause of human morbidity and mortality. We performed a genome-wide transcriptional survey of liver biopsies obtained from Chinese patients with chronic schistosomiasis only, or chronic schistosomiasis with a current or past history of viral hepatitis B. Both disease groups were compared with patients with no prior history or indicators of any liver disease. Analysis showed in the main, downregulation in gene expression, particularly those involved in signal transduction via EIF2 signalling and mTOR signalling, as were genes associated with cellular remodelling. Focusing on immune associated pathways, genes were generally downregulated. However, a set of three genes associated with granulocytes, MMP7, CLDN7, CXCL6 were upregulated. Differential gene profiles unique to schistosomiasis included the gene Granulin which was decreased despite being generally considered a marker for liver disease, and IGBP2 which is associated with increased liver size, and was the most upregulated gene in schistosomiasis only patients, all of which presented with hepatomegaly. The unique features of gene expression, in conjunction with previous reports in the murine model of the cellular composition of granulomas, granuloma formation and recovery, provide an increased understanding of the molecular immunopathology and general physiological processes underlying hepatic schistosomiasis.
Keyword Clinical
Hepatic fibrosis
Liver
Schistosoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Veterinary Science Publications
 
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