Host entry by gamma-herpesviruses - lessons from animal viruses?

Gillet, Laurent, Frederico, Bruno and Stevenson, Philip G. (2015) Host entry by gamma-herpesviruses - lessons from animal viruses?. Current Opinion in Virology, 15 34-40. doi:10.1016/j.coviro.2015.07.007

Author Gillet, Laurent
Frederico, Bruno
Stevenson, Philip G.
Title Host entry by gamma-herpesviruses - lessons from animal viruses?
Journal name Current Opinion in Virology   Check publisher's open access policy
ISSN 1879-6265
Publication date 2015-12-31
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.coviro.2015.07.007
Open Access Status Not yet assessed
Volume 15
Start page 34
End page 40
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Abstract The oncogenicity of gamma-herpesviruses (γHVs) motivates efforts to control them and their persistence makes early events key targets for intervention. Human γHVs are often assumed to enter naive hosts orally and infect B cells directly. However, neither assumption is supported by direct evidence, and vaccination with the Epstein-Barr virus (EBV) gp350, to block virion binding to B cells, failed to reduce infection rates. Thus, there is a need to re-evaluate assumptions about γHV host entry. Given the difficulty of analysing early human infections, potentially much can be learned from animal models. Genomic comparisons argue that γHVs colonized mammals long before humans speciation, and so that human γHVs are unlikely to differ dramatically in behaviour from those of other mammals. Murid Herpesvirus-4 (MuHV-4), which like EBV and the Kaposi's Sarcoma-associated Herpesvirus (KSHV) persists in memory B cells, enters new hosts via olfactory neurons and exploits myeloid cells to spread. Integrating these data with existing knowledge of human and veterinary γHVs suggests a new model of host entry, with potentially important implications for infection control.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Clinical Medical Virology Centre Publications
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