The emerging threat of multidrug-resistant Gram-negative bacteria in urology

Zowawi, Hosam M., Harris, Patrick N. A., Roberts, Matthew J., Tambyah, Paul A., Schembri, Mark A., Pezzani, M. Diletta, Williamson, Deborah A. and Paterson, David L. (2015) The emerging threat of multidrug-resistant Gram-negative bacteria in urology. Nature Reviews Urology, 12 10: 570-584. doi:10.1038/nrurol.2015.199

Author Zowawi, Hosam M.
Harris, Patrick N. A.
Roberts, Matthew J.
Tambyah, Paul A.
Schembri, Mark A.
Pezzani, M. Diletta
Williamson, Deborah A.
Paterson, David L.
Title The emerging threat of multidrug-resistant Gram-negative bacteria in urology
Journal name Nature Reviews Urology   Check publisher's open access policy
ISSN 1759-4820
Publication date 2015-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrurol.2015.199
Open Access Status Not Open Access
Volume 12
Issue 10
Start page 570
End page 584
Total pages 15
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
Antibiotic resistance in Gram-negative uropathogens is a major global concern. Worldwide, the prevalence of Enterobacteriaceae that produce extended-spectrum β-lactamase or carbapenemase enzymes continues to increase at alarming rates. Likewise, resistance to other antimicrobial agents including aminoglycosides, sulphonamides and fluoroquinolones is also escalating rapidly. Bacterial resistance has major implications for urological practice, particularly in relation to catheter-associated urinary tract infections (UTIs) and infectious complications following transrectal-ultrasonography-guided biopsy of the prostate or urological surgery. Although some new drugs with activity against Gram-negative bacteria with highly resistant phenotypes will become available in the near future, the existence of a single agent with activity against the great diversity of resistance is unlikely. Responding to the challenges of Gram-negative resistance will require a multifaceted approach including considered use of current antimicrobial agents, improved diagnostics (including the rapid detection of resistance) and surveillance, better adherence to basic measures of infection prevention, development of new antibiotics and research into non-antibiotic treatment and preventive strategies.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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Created: Mon, 17 Aug 2015, 12:01:06 EST by Roheen Gill on behalf of UQ Centre for Clinical Research