Low birthweight increases risk for cardiovascular disease hospitalisations in a remote Indigenous Australian community – a prospective cohort study

Arnold, Luke, Hoy, Wendy and Wang, Zhiqiang (2016) Low birthweight increases risk for cardiovascular disease hospitalisations in a remote Indigenous Australian community – a prospective cohort study. Australian and New Zealand Journal of Public Health, 40 S102-S106. doi:10.1111/1753-6405.12426


Author Arnold, Luke
Hoy, Wendy
Wang, Zhiqiang
Title Low birthweight increases risk for cardiovascular disease hospitalisations in a remote Indigenous Australian community – a prospective cohort study
Journal name Australian and New Zealand Journal of Public Health   Check publisher's open access policy
ISSN 1326-0200
1753-6405
Publication date 2016-04
Year available 2015
Sub-type Article (original research)
DOI 10.1111/1753-6405.12426
Open Access Status Not Open Access
Volume 40
Start page S102
End page S106
Total pages 5
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2016
Language eng
Formatted abstract
Objectives: To investigate the association between low birthweight (LBW; <2,500 grams) and cardiovascular disease (CVD) hospitalisations in adult life in a remote Indigenous Australian community.

Methods: This was a prospective cohort of 852 participants with recorded birthweight using community-wide health screening examinations conducted between 1992 and 1999 and hospitalisation records up to 2012. Cox proportional hazard models assessed the association between LBW and hypertension, major CVD (heart failure, myocardial infarction and stroke) and any CVD hospitalisations.

Results: There were 236 participants (28%) who had a low birthweight. The LBW group had a higher risk of developing any CVD (HR = 1.43, 95%CI 1.01–2.03), major CVD (HR = 1.51, 95%CI 0.93–2.47) and hypertension (HR = 1.83, 95%CI 1.09–2.96) than the normal birthweight (NBW) group (≥2,500 g). Women with LBW had more than 2.6 times the risk of a hospitalisation associated with hypertension compared to their NBW counterparts (HR = 2.61, 95%CI 1.38–4.93), but this relationship was not seen in men.

Conclusions and implications: LBW increased the risk of cardiovascular disease hospitalisations in adult life in this group. Further CVD prevention initiatives should continue to include LBW as a key predictor of CVD in this community. The mechanisms of gender influence on the hypertension relationship are unknown and require further investigation in indigenous populations worldwide.
Keyword Birthweight
Hypertension
Indigenous Australians
Cardiovascular disease
Adult
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 10 August 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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Created: Fri, 14 Aug 2015, 08:38:21 EST by Zhiqiang Wang on behalf of Medicine - Royal Brisbane and Women's Hospital