Inactive free : total prostate specific antigen ratios in ejaculate from men with suspected and known prostate cancer, compared with young control men

Clements, J. A., Merritt, T., DeVoss, K., Swanson, C. E., Hamlyn, L., Scells, B., Rohde, P., Lavin, M. F., Yaxley, J. and Gardiner, R. A. (2000) Inactive free : total prostate specific antigen ratios in ejaculate from men with suspected and known prostate cancer, compared with young control men. BJU International, 86 4: 453-458. doi:10.1046/j.1464-410X.2000.00835.x


Author Clements, J. A.
Merritt, T.
DeVoss, K.
Swanson, C. E.
Hamlyn, L.
Scells, B.
Rohde, P.
Lavin, M. F.
Yaxley, J.
Gardiner, R. A.
Title Inactive free : total prostate specific antigen ratios in ejaculate from men with suspected and known prostate cancer, compared with young control men
Journal name BJU International
ISSN 1464-410X
1464-4096
1358-8672
Publication date 2000
Sub-type Article (original research)
DOI 10.1046/j.1464-410X.2000.00835.x
Volume 86
Issue 4
Start page 453
End page 458
Total pages 6
Place of publication London
Publisher Blackwell Science
Language eng
Subject 1103 Clinical Sciences
Abstract Objective To measure free:total prostate specific antigen (PSA) ratios in ejaculate from men with suspected and known prostate cancer, and in young control men, to determine if this ratio might be useful in discriminating benign from malignant prostatic conditions. Patients, subjects and methods Forty-seven men with prostate cancer (positive biopsies), 52 men with suspected prostate cancer but who had negative biopsies and 28 young men (< 30 years old) and with no family history of cancer, provided either a single ejaculate specimen (total 59) or multiple specimens (total 193) on subsequent occasions. Free and total PSA were measured using appropriate assays. All specimens were diluted in a PSA-negative female serum pool. Results The median free:total PSA ratios were 0.76-0.81 among the patient groups and control men, and there was no statistical difference between the groups. These data presumably only reflect the inactive component of free PSA, given that any alpha(2)-macroglobulin or alpha(1)-antichymotrypsin in the assay serum diluent was likely to have bound the active free PSA component in these samples. Similar results were obtained from those providing single and multiple samples, suggesting that a single specimen is sufficient to reflect the seminal plasma free:total PSA ratio over that period. There was no relationship between seminal plasma free:total PSA ratio and age for the controls or the positive biopsy group, although there was a negative relationship (i.e. a decline with age) that almost reached significance in those with negative biopsies (P = 0.058, R-2 = 0.07). Conclusions This is the first report of free:total PSA ratios in the ejaculate of men with suspected and known prostate cancer compared with young control men. Although no significant changes were detected in the free:total PSA ratios in ejaculate, these results may be confounded by differences in ratios with age, as is the case for serum PSA or different molecular forms of PSA. Indeed, these data suggest that a large proportion of free PSA in seminal plasma may be inactive. Further studies are needed to determine the potential utility of measuring free:total PSA, or other candidate markers, in ejaculate to better discriminate benign from malignant prostate disease.
Keyword Urology & Nephrology
Inactive Free
Ejaculate
Prostate Cancer
Benign
Discrimination
Seminal Plasma
Human-semen
Serum
Psa
Cells
Hk2
Biopsies
Complex
Benign
Alpha-1-antichymotrypsin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Business School Publications
School of Medicine Publications
 
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Created: Mon, 13 Aug 2007, 11:57:58 EST