Segmented Highly Branched Copolymers: Rationally Designed Macromolecules for Improved and Tunable 19F MRI

Wang, Kewei, Peng, Hui, Thurecht, Kristofer J., Puttick, Simon and Whittaker, Andrew K. (2015) Segmented Highly Branched Copolymers: Rationally Designed Macromolecules for Improved and Tunable 19F MRI. Biomacromolecules, 16 9: 2827-2839. doi:10.1021/acs.biomac.5b00800


Author Wang, Kewei
Peng, Hui
Thurecht, Kristofer J.
Puttick, Simon
Whittaker, Andrew K.
Title Segmented Highly Branched Copolymers: Rationally Designed Macromolecules for Improved and Tunable 19F MRI
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
1526-4602
Publication date 2015-07-28
Year available 2015
Sub-type Article (original research)
DOI 10.1021/acs.biomac.5b00800
Volume 16
Issue 9
Start page 2827
End page 2839
Total pages 13
Place of publication Washington, DC United States
Publisher American Chemical Society
Collection year 2016
Language eng
Formatted abstract
Highly branched polymers are a promising platform for the design of next-generation contrast agents for 19F magnetic resonance imaging (MRI). A series of segmented highly branched polymers (SHBPs) consisting of fluoro- and PEG-based monomers were synthesized by self-condensing vinyl copolymerization (SCVP) using the reversible addition–fragmentation chain transfer (RAFT) technique. SHBPs having different compositions and degrees of branching were obtained by varying the monomer type and feed ratio of monomer to chain transfer agent (CTA). The chemical structures and physical properties of the branched polymers were thoroughly characterized in detail by NMR, SEC and DSC. The systematic variation in structural parameters allowed the relationships between molecular structure, sequence distribution, and imaging performance to be examined. The 19F NMR properties were strongly affected by the sequence distribution of the fluorinated monomers, the type of polymer backbone and the degree of branching. As a result, SHBPs consisting of statistical copolymeric segments of acrylate units were identified as excellent candidates for imaging due to a single 19F signal, long T2 relaxation times, and high fluorine contents. The SHBPs could be all imaged or selectively imaged by taking advantage of the differences in relaxation times, demonstrating tunable and selective imaging performance through tailoring the structure and composition of the SHBPs.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Thu, 13 Aug 2015, 16:29:02 EST by Simon Puttick on behalf of Aust Institute for Bioengineering & Nanotechnology