Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep

Marini, D., Pippia, J., Colditz, I.G., Hinch, G., Petherick, J. C. and Lee, C. (2015) Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. Australian Veterinary Journal, 93 8: 265-270. doi:10.1111/avj.12351


Author Marini, D.
Pippia, J.
Colditz, I.G.
Hinch, G.
Petherick, J. C.
Lee, C.
Title Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep
Journal name Australian Veterinary Journal   Check publisher's open access policy
ISSN 1751-0813
0005-0423
Publication date 2015-08
Sub-type Article (original research)
DOI 10.1111/avj.12351
Open Access Status Not Open Access
Volume 93
Issue 8
Start page 265
End page 270
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Objective:  To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep.

Design:  Randomised experimental design with four treatment groups: three NSAID groups and one control group (n = 10/group). The study animals were 40 18-month-old Merino ewes with an average weight of 31.4 ± 0.5 kg.

Methods:  Treatment was given orally at 24 h intervals for 6 days at dose rates expected to achieve therapeutic levels in sheep: carprofen (8.0 mg/kg), ketoprofen (8.0 mg/kg) and flunixin (4.0 mg/kg). Oil of turpentine (0.1 mL) was injected into a forelimb of each sheep to induce inflammation and pain; responses (force plate pressure, skin temperature, limb circumference, haematology and plasma cortisol) were measured at 0, 3, 6, 9, 12, 24, 36, 48, 72 and 96 h post-injection. NSAID concentrations were determined by ultra-high-pressure liquid chromatography.

Results:  The NSAIDs were detectable in ovine plasma 2 h after oral administration, with average concentrations of 4.5–8.4 µg/mL for ketoprofen, 2.6–4.1 µg/mL for flunixin and 30–80 µg/mL for carprofen. NSAID concentrations dropped 24 h after administration. Pain response to an oil of turpentine injection was assessed using the measures applied but no effect of the NSAIDs was observed. Although this pain model has been previously validated, the responses observed in this study differed from those in the previous study.

Conclusions and clinical relevance:  The three NSAIDs reached inferred therapeutic concentrations in blood at 2 h after oral administration. The oil of turpentine lameness model may need further validation.
Keyword Animal welfare
Non-steroidal anti-inflammatory drugs
Pain
Sheep
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2016 Collection
 
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