Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia

Marshall, Helen S., Richmond, Peter, Nissen, Michael, Lambert, Stephen, Booy, Robert, Reynolds, Graham, Sebastian, Shite, Pride, Michael, Jansen, Kathrin U., Anderson, Annaliesa S. and Scully, Ingrid L. (2015) Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia. Pediatric Infectious Disease Journal, 34 8: 831-838. doi:10.1097/INF.0000000000000745

Author Marshall, Helen S.
Richmond, Peter
Nissen, Michael
Lambert, Stephen
Booy, Robert
Reynolds, Graham
Sebastian, Shite
Pride, Michael
Jansen, Kathrin U.
Anderson, Annaliesa S.
Scully, Ingrid L.
Title Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia
Journal name Pediatric Infectious Disease Journal   Check publisher's open access policy
ISSN 1532-0987
Publication date 2015-08-21
Sub-type Article (original research)
DOI 10.1097/INF.0000000000000745
Open Access Status Not Open Access
Volume 34
Issue 8
Start page 831
End page 838
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams and Wilkins
Collection year 2016
Language eng
Formatted abstract
Background: Group A streptococci (GAS) and other [beta]-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children.

Methods: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0–10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody.

Results: GAS-positive culture prevalence in throat swabs was 5.0% (range 0–10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (<1%). The scp gene was present in all 22 isolates evaluated. As age of child increased, the rate of carriage increased; odds ratio, 1.14 (1.00, 1.29); P = 0.50. Geometric mean anti-SCP titers increased with each age-band from 2 to 7 years, then plateaued. Age, geographic location and number of children within the household were significantly associated with the presence of anti-SCP antibodies.

Conclusions: Children are exposed to GAS and other BHS at a young age, which is important for determining the target age for vaccination to protect before the period of risk.
Keyword Acute rheumatic fever
Anti-streptococcal C5a peptidase gene
GAS vaccines
Group A streptococcus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
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