Are obesity risk genes associated with binge eating in adolescence?

Micali, Nadia, Field, Alison E., Treasure, Janet L. and Evans, David M. (2015) Are obesity risk genes associated with binge eating in adolescence?. Obesity, 23 8: 1729-1736. doi:10.1002/oby.21147

Author Micali, Nadia
Field, Alison E.
Treasure, Janet L.
Evans, David M.
Title Are obesity risk genes associated with binge eating in adolescence?
Journal name Obesity   Check publisher's open access policy
ISSN 1930-739X
Publication date 2015-08-01
Year available 2015
Sub-type Article (original research)
DOI 10.1002/oby.21147
Open Access Status Not yet assessed
Volume 23
Issue 8
Start page 1729
End page 1736
Total pages 8
Place of publication Hoboken NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Cognitions and behaviors characteristic of binge eating are associated with a polymorphism in the FTO gene, robustly related to body mass index (BMI) and obesity risk. We investigated the association between binge eating and the individual and combined effect of 32 SNPs robustly associated with BMI in a population-based sample. We hypothesized that higher BMI and binge eating might share a common genetic etiology.

Binge eating was assessed in adolescents from the Avon Longitudinal Study of Parents and Children at age 14 (n = 5,958) and 16 years (n = 4,948). We tested associations between 32 BMI-related SNPs and binge eating in crude and BMI-, age-, and gender-adjusted regression models.

Crude analyses showed an association between binge eating and rs1558902 (FTO) that persisted after adjustment for BMI (OR = 1.20, P = 8 × 10−3). A weighted allelic score consisting of all 32 BMI-related SNPs was associated with binge eating (P = 8 × 10−4); this association attenuated (P = 0.08) when rs1558902 was removed from the weighted allelic score.

BMI-related genes are associated with adolescent binge eating, in particular an FTO polymorphism. Although replication is needed, our findings have biological plausibility and are consistent with a postulated effect of FTO on appetite and food intake. Future studies should aim to understand the mechanisms underlying the relationship between FTO, binge eating, and obesity.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
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