MRI-determined lumbar muscle morphometry in man and sheep: Potential biomechanical implications for ovine model to human spine translation

Valentin, Stephanie, Licka, Theresia F and Elliott, James (2015) MRI-determined lumbar muscle morphometry in man and sheep: Potential biomechanical implications for ovine model to human spine translation. Journal of Anatomy, 227 4: 506-513. doi:10.1111/joa.12354


Author Valentin, Stephanie
Licka, Theresia F
Elliott, James
Title MRI-determined lumbar muscle morphometry in man and sheep: Potential biomechanical implications for ovine model to human spine translation
Journal name Journal of Anatomy   Check publisher's open access policy
ISSN 1469-7580
0021-8782
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1111/joa.12354
Open Access Status Not yet assessed
Volume 227
Issue 4
Start page 506
End page 513
Total pages 8
Place of publication London, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Abstract The sheep is a commonly used animal model for human lumbar spine surgery, but only in vitro investigations comparing the human and ovine spine exist. Spinal musculature has previously not been compared between man and sheep. This additional knowledge could further indicate to what extent these species are biomechanically similar. Therefore, the purpose of the study was to investigate spinal muscle morphometric properties using magnetic resonance imaging (MRI) in different age groups of healthy human participants and sheep in vivo. Healthy human participants (n = 24) and sheep (n = 17) of different age groups underwent T1-weighted MRI of the lumbar spine. Regions of interest of the muscles erector spinae (ES), multifidus (M) and psoas (PS) were identified. The ratio of flexor to extensor volume, ratio of M to ES volume, and muscle fat relative to an area of intermuscular fat were calculated. Sheep M to ES ratio was significantly smaller than in the human participants (sheep 0.16 ± 0.02; human 0.37 ± 0.05; P < 0.001), although flexor to extensor ratio was not significantly different between species (human 0.39 ± 0.08; sheep 0.43 ± 0.05; P = 0.06). Age did not influence any muscle ratio outcome. Sheep had significantly greater extensor muscle fat compared with the human participants (M left human 40.64%, sheep 53.81%; M right human 39.17%, sheep 51.33%; ES left human 40.86%, sheep 51.29%; ES right human 35.93%, sheep 44.38%; all median values; all P < 0.001), although PS did not show any significant between-species differences (PS left human 36.89%, sheep 33.67%; PS right human 32.78%, sheep 30.09%; P < 0.05). The apparent differences in the size and shape of sheep and human lumbar spine muscles may indicate dissimilar biomechanical and functional demands, which is an important consideration when translating to human surgical models.
Keyword Lumbar spine
Magnetic resonance imaging
Muscle
Muscle fatty infiltrate
Ovine model
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Health and Rehabilitation Sciences Publications
 
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