MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells

Tsuyama, Jun, Bunt, Jens, Richards, Linda J., Iwanari, Hiroko, Mochizuki, Yasuhiro, Hamakubo, Takao, Shimazaki, Takuya and Okano, Hideyuki (2015) MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells. Stem Cell Reports, 5 3: 365-377. doi:10.1016/j.stemcr.2015.06.006


Author Tsuyama, Jun
Bunt, Jens
Richards, Linda J.
Iwanari, Hiroko
Mochizuki, Yasuhiro
Hamakubo, Takao
Shimazaki, Takuya
Okano, Hideyuki
Title MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells
Journal name Stem Cell Reports   Check publisher's open access policy
ISSN 2213-6711
Publication date 2015-09-08
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.stemcr.2015.06.006
Open Access Status DOI
Volume 5
Issue 3
Start page 365
End page 377
Total pages 13
Place of publication Cambridge, MA, United States
Publisher Cell Press (Elsevier)
Collection year 2016
Language eng
Abstract Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. Inhibition of miR-153 in early neurogenic NSPCs induced precocious gliogenesis, whereas NFIA/B overexpression rescued the anti-gliogenic phenotypes induced by miR-153 OE. Our results indicate that miR-mediated fine control of NFIA/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by NSPCs in the developing CNS.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Biomedical Sciences Publications
 
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