Characterisation of the Equine adenovirus 2 genome

Giles, Carla, Vanniasinkam, Thiru, Barton, Mary and Mahony, Timothy J. (2015) Characterisation of the Equine adenovirus 2 genome. Veterinary Microbiology, 179 3-4: 184-189. doi:10.1016/j.vetmic.2015.07.024

Author Giles, Carla
Vanniasinkam, Thiru
Barton, Mary
Mahony, Timothy J.
Title Characterisation of the Equine adenovirus 2 genome
Formatted title
Characterisation of the Equine adenovirus 2 genome
Journal name Veterinary Microbiology   Check publisher's open access policy
ISSN 1873-2542
Publication date 2015-09-30
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.vetmic.2015.07.024
Open Access Status Not yet assessed
Volume 179
Issue 3-4
Start page 184
End page 189
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Equine adenovirus 2 (EAdV-2) is one of two serotypes of adenoviruses known to infect equines. Initial studies did not associate EAdV-2 infections with any specific clinical syndromes, although more recent evidence suggests that EAdV-2 may be associated with clinical and subclinical gastrointestinal infections of foals and adults respectively. In contrast, Equine adenovirus 1 is well recognised as a pathogen associated with upper respiratory tract infections of horses. In this study the complete genome sequence of EAdV-2 is reported. As expected, genes common to the adenoviruses were identified. Phylogenetic reconstructions using selected EAdV-2 genes confirmed the classification of this virus within the Mastadenovirus genus, and supported the hypothesis that EAdV-2 and EAdV-1 have evolved from separate lineages within the adenoviruses. One spliced open reading frame was identified that encoded for a polypeptide with high similarity to the pIX and E1b_55K adenovirus homologues and was designated pIX_E1b_55K. In addition to this fused version of E1b_55K, a separate E1b_55K encoding gene was also identified. These polypeptides do not appear to have evolved from a gene duplication event as the fused and unfused E1b_55K were most similar to E1b_55K homologues from the Atadenovirus and Mastadenovirus genera respectively. The results of this study suggest that EAdV-2 has an unusual evolutionary history that warrants further investigation.
Keyword Equine adenovirus 2
Complete genome
Next generation sequencing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2016 Collection
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