Classifying cancers based on T-cell infiltration and PD-L1

Teng, Michele W. L., Ngiow, Shin Foong, Ribas, Antoni and Smyth, Mark J. (2015) Classifying cancers based on T-cell infiltration and PD-L1. Cancer Research, 75 11: 2139-2145. doi:10.1158/0008-5472.CAN-15-0255


Author Teng, Michele W. L.
Ngiow, Shin Foong
Ribas, Antoni
Smyth, Mark J.
Title Classifying cancers based on T-cell infiltration and PD-L1
Journal name Cancer Research   Check publisher's open access policy
ISSN 0008-5472
1538-7445
Publication date 2015-06-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1158/0008-5472.CAN-15-0255
Open Access Status Not Open Access
Volume 75
Issue 11
Start page 2139
End page 2145
Total pages 7
Place of publication Philadelphia, PA United States
Publisher American Association for Cancer Research
Collection year 2016
Language eng
Abstract Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor-infiltrating lymphocytes and programmed death-ligand 1 (PD-L1) expression. We review this stratification and the latest in a series of results that shed light on new approaches for rationally designing ideal combination cancer therapies based on tumor immunology.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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