The mechanism or mechanisms driving atopic asthma initiation: the infant respiratory microbiome moves to center stage

Holt, Patrick G. (2015) The mechanism or mechanisms driving atopic asthma initiation: the infant respiratory microbiome moves to center stage. Journal of Allergy and Clinical Immunology, 136 1: 15-22. doi:10.1016/j.jaci.2015.05.011


Author Holt, Patrick G.
Title The mechanism or mechanisms driving atopic asthma initiation: the infant respiratory microbiome moves to center stage
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 1097-6825
0091-6749
Publication date 2015-07
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jaci.2015.05.011
Open Access Status Not yet assessed
Volume 136
Issue 1
Start page 15
End page 22
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Mosby
Collection year 2016
Language eng
Abstract Developments over the last 5 to 10 years, principally from studies on comprehensively phenotyped prospective birth cohorts, have highlighted the important role of viral respiratory tract infections during infancy and early childhood, particularly those occurring against a background of pre-existing sensitization to perennial aeroallergens, in driving the development of early-onset atopic asthma. Although debate surrounding the mechanism or mechanisms governing this causal pathway remains intense, demonstration of the capacity of pretreatment with anti-IgE antibody to blunt seasonal virus-associated asthma exacerbations in children provides strong support for the underlying concept. However, emerging data appear set to further complicate this picture. Notably, a combination of culture-based studies and complementary population-wide bacterial metagenomic data suggests that parallel host-bacteria interactions during infancy might play an additional role in modulating this causal pathway, as well as contributing independently to pathogenesis. These and related issues surrounding development of immune competence during the crucial early postnatal period, when these pathways are maximally active, are discussed below.
Keyword Asthma
Atopy
Infancy
Viral infections
Nasopharyngeal microbiome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
Child Health Research Centre Publications
 
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