The occurence and toxicity of indospicine to grazing animals

Fletcher, Mary T., Al Jassim, Rafat A.M and Cawdell-Smith, A. Judith (2015) The occurence and toxicity of indospicine to grazing animals. Agriculture, 5 3: 427-440. doi:10.3390/agriculture5030427

Author Fletcher, Mary T.
Al Jassim, Rafat A.M
Cawdell-Smith, A. Judith
Title The occurence and toxicity of indospicine to grazing animals
Journal name Agriculture   Check publisher's open access policy
ISSN 2077-0472
Publication date 2015-07-13
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/agriculture5030427
Open Access Status DOI
Volume 5
Issue 3
Start page 427
End page 440
Total pages 14
Place of publication Basel, Switzerland
Publisher MDPI AG
Collection year 2016
Language eng
Formatted abstract
Indospicine is a non-proteinogenic amino acid which occurs in Indigofera species with widespread prevalence in grazing pastures across tropical Africa, Asia, Australia, and the Americas. It accumulates in the tissues of grazing livestock after ingestion of Indigofera. It is a competitive inhibitor of arginase and causes both liver degeneration and abortion. Indospicine hepatoxicity occurs universally across animal species but the degree varies considerably between species, with dogs being particularly sensitive. The magnitude of canine sensitivity is such that ingestion of naturally indospicine-contaminated horse and camel meat has caused secondary poisoning of dogs, raising significant industry concern. Indospicine impacts on the health and production of grazing animals per se has been less widely documented. Livestock grazing Indigofera have a chronic and cumulative exposure to this toxin, with such exposure experimentally shown to induce both hepatotoxicity and embryo-lethal effects in cattle and sheep. In extensive pasture systems, where animals are not closely monitored, the resultant toxicosis may well occur after prolonged exposure but either be undetected, or even if detected not be attributable to a particular cause. Indospicine should be considered as a possible cause of animal poor performance, particularly reduced weight gain or reproductive losses, in pastures where Indigofera are prevalent.
Keyword Indospicine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes, and can be downloaded free from this site.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Agriculture and Food Sciences
Queensland Alliance for Agriculture and Food Innovation
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
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Created: Tue, 04 Aug 2015, 10:20:40 EST by Dr Mary Fletcher on behalf of School of Chemistry & Molecular Biosciences