Suppression of inflammation by helminths: a role for the gut microbiota?

Giacomin, Paul, Croese, John, Krause, Lutz, Loukas, Alex and Cantacessi, Cinzia (2015) Suppression of inflammation by helminths: a role for the gut microbiota?. Philosophical Transactions of the Royal Society B: Biological Sciences, 370 1675: . doi:10.1098/rstb.2014.0296


Author Giacomin, Paul
Croese, John
Krause, Lutz
Loukas, Alex
Cantacessi, Cinzia
Title Suppression of inflammation by helminths: a role for the gut microbiota?
Journal name Philosophical Transactions of the Royal Society B: Biological Sciences   Check publisher's open access policy
ISSN 1471-2970
0962-8436
Publication date 2015-08-19
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1098/rstb.2014.0296
Open Access Status DOI
Volume 370
Issue 1675
Total pages 6
Place of publication London, United Kingdom
Publisher The Royal Society Publishing
Collection year 2016
Language eng
Abstract Multiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of host–parasite–microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis of the role of the gut microbiota in helminth-induced suppression of inflammation.
Keyword Helminth-induced suppression of inflammation
Hookworms
Host–parasite interactions
Microbial richness
Microbiota
Whipworms
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
 
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