Placental and fetal cysteine dioxygenase gene expression in mouse gestation

Rakoczy, J., Lee, S., Weerasekera, S. J., Simmons, D. G. and Dawson, P. A. (2015) Placental and fetal cysteine dioxygenase gene expression in mouse gestation. Placenta, 36 8: 956-959. doi:10.1016/j.placenta.2015.06.003


Author Rakoczy, J.
Lee, S.
Weerasekera, S. J.
Simmons, D. G.
Dawson, P. A.
Title Placental and fetal cysteine dioxygenase gene expression in mouse gestation
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2015-06-19
Sub-type Article (original research)
DOI 10.1016/j.placenta.2015.06.003
Volume 36
Issue 8
Start page 956
End page 959
Total pages 4
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Nutrient sulfate is important for fetal development. The fetus has a limited capacity to generate sulfate and relies on maternal sulfate supplied via the placenta. The gestational age when fetal sulfate generation begins is unknown but would require cysteine dioxygenase (CDO1) which mediates a major step of sulfate production from cysteine. We investigated the ontogeny of Cdo1 mRNA expression in mouse fetal and placental tissues, which showed increasing levels from embryonic day 10.5 and was localised to the decidua and several fetal tissues including nasal cavities and brain. These findings suggest a role for Cdo1 in sulfate generation from mid-gestation.
Keyword Sulfate
Pregnancy
Placenta
Decidua
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article in press corrected proof.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
School of Biomedical Sciences Publications
 
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