Left ventricular systolic dysfunction in asymptomatic black hypertensive subjects

Ojji, Dike, Atherton, John, Sliwa, Karen, Alfa, Jacob, Ngabea, Murtala and Opie, Lionel (2015) Left ventricular systolic dysfunction in asymptomatic black hypertensive subjects. American Journal of Hypertension, 28 7: 924-929. doi:10.1093/ajh/hpu247


Author Ojji, Dike
Atherton, John
Sliwa, Karen
Alfa, Jacob
Ngabea, Murtala
Opie, Lionel
Title Left ventricular systolic dysfunction in asymptomatic black hypertensive subjects
Journal name American Journal of Hypertension   Check publisher's open access policy
ISSN 1941-7225
0895-7061
Publication date 2015-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/ajh/hpu247
Open Access Status Not yet assessed
Volume 28
Issue 7
Start page 924
End page 929
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Formatted abstract
BACKGROUND Hypertension has been established as one of the commonest causes of heart failure especially in sub-Saharan Africa. We have previously observed a high prevalence of left ventricular (LV) systolic dysfunction in hypertensive heart failure patients in Nigeria despite a low prevalence of ischemic heart disease. The present study was, therefore, undertaken to assess the prevalence of asymptomatic LV systolic dysfunction in hypertensive black African subjects with no history of heart failure.

METHODS One thousand nine hundred forty-seven hypertensive subjects without heart failure presenting to the Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Nigeria, from April 2006 to August 2013 had clinical and echocardiographic evaluation.

RESULTS Nine hundred fifty-three (48.9%) were males and 994 (51.1%) were females. One thousand eight hundred seventeen (93.3%) had normal LV systolic function (LV ejection fraction (LVEF) ≥ 54%), 68 (3.5%) had mild LV systolic dysfunction (LVEF 45–54%), 43 (2.3%) had moderate LV systolic dysfunction (LVEF 30–44%), and 16 (0.9%) had severe LV systolic dysfunction (LVEF < 30%). Male subjects had worse LV systolic function compared to women (mean LVEF 73.2% vs. 75.6%, P value < 0.0001) and diabetic subjects had worse LV systolic function compared to nondiabetic subjects (LVEF 72.3% vs. 75.7%, P = 0.02). In multivariate regression analysis, lower LVEF as a continuous variable was associated with older age, male sex, diabetes mellitus, LV mass indexed for body surface area, diastolic blood pressure, posterior wall thickness in diastole, left atrial diameter, and LV internal diameter in diastole.

CONCLUSIONS In a cohort of asymptomatic Black hypertensive subjects, 6.7% had LV systolic dysfunction, which was associated with male gender, diabetes mellitus, and larger LV mass.
Keyword Blood pressure
Hypertension
Left ventricular
Systolic dysfunction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
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