Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

Ngo, S. T., Steyn, F. J., Huang, L., Mantovani, S., Pfluger, C. M. M., Woodruff, T. M., O'Sullivan, J. D., Henderson, R. D. and McCombe, P. A. (2015) Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 357 1-2: 22-27. doi:10.1016/j.jns.2015.06.053

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Author Ngo, S. T.
Steyn, F. J.
Huang, L.
Mantovani, S.
Pfluger, C. M. M.
Woodruff, T. M.
O'Sullivan, J. D.
Henderson, R. D.
McCombe, P. A.
Title Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
ISSN 1878-5883
0022-510X
Publication date 2015-10-15
Sub-type Article (original research)
DOI 10.1016/j.jns.2015.06.053
Open Access Status DOI
Volume 357
Issue 1-2
Start page 22
End page 27
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the loss of upper cortical and lower motor neurons. ALS causes death within 2–5 years of diagnosis. Diet and body mass index influence the clinical course of disease, however there is limited information about the expression of metabolic proteins and fat-derived cytokines (adipokines) in ALS. In healthy controls and subjects with ALS, we have measured levels of proteins and adipokines that influence metabolism. We find altered levels of active ghrelin, gastric inhibitory peptide (GIP), pancreatic polypeptide (PP), lipocalin-2, plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6) and 8 (IL-8), and tumor necrosis factor alpha (TNFα) in the plasma of ALS patients relative to controls. We also observe a positive correlation between the expression of plasma nerve growth factor (NGF) relative to disease duration, and an inverse correlation between plasma glucagon and the ALS functional rating scale-revised (ALSFRS-R). Further studies are required to determine whether altered expression of metabolic proteins and adipokines contribute to motor neuron vulnerability and how these factors act to modify the course of disease.
Keyword Amyotrophic lateral sclerosis
Metabolism
Body mass index
Adipose
Adipokines
Neurodegeneration
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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