The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

Zhang, Lifang, Wu, Jianhong, Ling, Ming Tat, Zhao, Liang and Zhao, Kong-Nan (2015) The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses. Molecular Cancer, 14 1: . doi:10.1186/s12943-015-0361-x


Author Zhang, Lifang
Wu, Jianhong
Ling, Ming Tat
Zhao, Liang
Zhao, Kong-Nan
Title The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses
Journal name Molecular Cancer   Check publisher's open access policy
ISSN 1476-4598
Publication date 2015-04-17
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s12943-015-0361-x
Open Access Status DOI
Volume 14
Issue 1
Total pages 28
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Abstract Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by HPV infection is driven by the sustained expression of two oncogenes E6 and E7. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways that may be equally important for transformation. Among these pathways, the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling cascade plays a very important role in HPV-induced carcinogenesis by acting through multiple cellular and molecular events. In this review, we summarize the frequent amplification of PI3K/Akt/mTOR signals in HPV-induced cancers and discuss how HPV oncogenes E6/E7/E5 activate the PI3K/Akt/mTOR signalling pathway to modulate tumor initiation and progression and affect patient outcome. Improvement of our understanding of the mechanism by which the PI3K/Akt/mTOR signalling pathway contributes to the immortalization and carcinogenesis of HPV-transduced cells will assist in devising novel strategies for preventing and treating HPV-induced cancers.
Keyword Cancer
Human papillomavirus
E6
E7
E5
Phosphatidylinositol 3-kinase (PI3K)
Akt
Mammalian target of rapamycin (mTOR)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
Institute for Molecular Bioscience - Publications
 
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