International pediatric non-Hodgkin lymphoma response criteria

Sandlund, John T., Guillerman, R. Paul, Perkins, Sherrie L., Pinkerton, C. Ross, Rosolen, Angelo, Patte, Catherine, Reiter, Alfred and Cairo, Mitchell S. (2015) International pediatric non-Hodgkin lymphoma response criteria. Journal of Clinical Oncology, 33 18: 2106-2111. doi:10.1200/JCO.2014.59.0745

Author Sandlund, John T.
Guillerman, R. Paul
Perkins, Sherrie L.
Pinkerton, C. Ross
Rosolen, Angelo
Patte, Catherine
Reiter, Alfred
Cairo, Mitchell S.
Title International pediatric non-Hodgkin lymphoma response criteria
Journal name Journal of Clinical Oncology   Check publisher's open access policy
ISSN 1527-7755
Publication date 2015-06-20
Year available 2015
Sub-type Article (original research)
DOI 10.1200/JCO.2014.59.0745
Open Access Status Not yet assessed
Volume 33
Issue 18
Start page 2106
End page 2111
Total pages 6
Place of publication Alexandria, VA United States
Publisher American Society of Clinical Oncology
Collection year 2016
Language eng
Formatted abstract
Purpose Response criteria are well established for adult patients with non-Hodgkin lymphoma (NHL). A revised set of response criteria in adults with NHL was recently published. However, NHL in children and adolescents involves different histologies, primary sites of disease, patterns of metastatic spread, approaches to therapy, and responses to treatment compared with adult NHL. However, there are no standardized response criteria specific to pediatric NHL. Therefore, we developed international standardized methods for assessing response to therapy in children and adolescents with NHL.

Methods An international multidisciplinary group of pediatric oncologists, pathologists, biologists, and radiologists convened during and after the Third and Fourth International Childhood, Adolescent and Young Adult NHL Symposia to review existing response and outcome data, develop methods for response evaluation that reflect incorporation of more sensitive technologies currently in use, and incorporate primary and metastatic sites of disease for the evaluation of therapeutic response in children and adolescents with NHL.

Results Using the current adult NHL response criteria as a starting point, international pediatric NHL response criteria were developed incorporating both contemporary diagnostic imaging and pathology techniques, including novel molecular and flow cytometric technologies used for the determination of minimal residual disease.

Conclusion Use of the international pediatric NHL response criteria in children and adolescents receiving therapy for NHL incorporates data obtained from new and more sensitive technologies that are now being widely used for disease evaluation, providing a standardized means for reporting treatment response.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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