Revised international pediatric non-Hodgkin lymphoma staging system

Rosolen, Angelo, Perkins, Sherrie L., Pinkerton, C. Ross, Guillerman, R. Paul, Sandlund, John T., Patte, Catherine, Reiter, Alfred and Cairo, Mitchell S. (2015) Revised international pediatric non-Hodgkin lymphoma staging system. Journal of Clinical Oncology, 33 18: 2112-2118. doi:10.1200/JCO.2014.59.7203


Author Rosolen, Angelo
Perkins, Sherrie L.
Pinkerton, C. Ross
Guillerman, R. Paul
Sandlund, John T.
Patte, Catherine
Reiter, Alfred
Cairo, Mitchell S.
Title Revised international pediatric non-Hodgkin lymphoma staging system
Journal name Journal of Clinical Oncology   Check publisher's open access policy
ISSN 1527-7755
0732-183X
Publication date 2015-06-20
Year available 2015
Sub-type Article (original research)
DOI 10.1200/JCO.2014.59.7203
Open Access Status Not yet assessed
Volume 33
Issue 18
Start page 2112
End page 2118
Total pages 7
Place of publication Alexandria, VA United States
Publisher American Society of Clinical Oncology
Collection year 2016
Language eng
Formatted abstract
Purpose Treatment and prognosis of pediatric non-Hodgkin lymphoma (NHL) have improved dramatically in the last 30 years. However, the St Jude NHL staging classification for pediatric NHL was developed more than 35 years ago. The most recent Lugano lymphoma staging classification focused on adult lymphoma. Furthermore, major limitations of the current pediatric NHL staging classification include lack of consideration of new distinct pediatric NHL histologic entities; absence of recognition of frequent skin, bone, kidney, ovarian, and other organ involvement; and lack of newer precise methods to detect bone marrow and CNS involvement, minimal disease quantification, and highly sensitive imaging technologies.

Methods An international multidisciplinary expert panel convened in Frankfurt, Germany, in 2009 at the Third International Childhood, Adolescent and Young Adult NHL Symposium to develop a revised international pediatric NHL staging system (IPNHLSS), addressing limitations of the current pediatric NHL staging system and creating a revised classification. Evidence-based disease distribution and behavior were reviewed from multiple pediatric cooperative group NHL studies.

Results A revised IPNHLSS was developed incorporating new histologic entities, extranodal dissemination, improved diagnostic methods, and advanced imaging technology.

Conclusion This revised IPNHLSS will facilitate more precise staging for children and adolescents with NHL and facilitate comparisons of efficacy across different treatment strategies, various institutions, multicenter trials, and cooperative groups by allowing for reproducible pediatric-based staging at diagnosis and relapse.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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