Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos

Austen, Jill M., Reid, Simon A., Robinson, Derrick R., Friend, James A., Ditcham, William G. F., Irwin, Peter J. and Ryan, Una (2015) Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos. Parasitology, 142 11: 1443-1452. doi:10.1017/S0031182015000785


Author Austen, Jill M.
Reid, Simon A.
Robinson, Derrick R.
Friend, James A.
Ditcham, William G. F.
Irwin, Peter J.
Ryan, Una
Title Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos
Formatted title
Investigation of the morphological diversity of the potentially zoonotic Trypanosoma copemani in quokkas and Gilbert's potoroos
Journal name Parasitology   Check publisher's open access policy
ISSN 0031-1820
1469-8161
Publication date 2015-09
Year available 2015
Sub-type Article (original research)
DOI 10.1017/S0031182015000785
Open Access Status Not Open Access
Volume 142
Issue 11
Start page 1443
End page 1452
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2016
Language eng
Formatted abstract
Trypanosomes are blood-borne parasites that can cause severe disease in both humans and animals, yet little is known of the pathogenicity and life-cycles of trypanosomes in native Australian mammals. Trypanosoma copemani is known to be infective to a variety of Australian marsupials and has recently been shown to be potentially zoonotic as it is resistant to normal human serum. In the present study, in vivo and in vitro examination of blood and cultures from Australian marsupials was conducted using light microscopy, immunofluorescence, scanning electron microscopy and fluorescence in situ hybridization. Promastigote, sphaeromastigote and amastigote life-cycle stages were detected in vivo and in vitro. Novel trypanosome-like stages were also detected both in vivo and in vitro representing an oval stage, an extremely thin stage, an adherent stage and a tiny round stage. The tiny round and adherent stages appeared to adhere to erythrocytes causing potential haematological damage with clinical effects similar to haemolytic anaemia. The present study shows for the first time that trypomastigotes are not the only life-cycle stages circulating within the blood stream of trypanosome infected Australian native marsupials and provides insights into possible pathogenic mechanisms of this potentially zoonotic trypanosome species.
Keyword Trypanosome
T. copemani
Marsupial
Setonix brachyurus
Potorous gilbertii
Novel life cycle stages
Pathogenesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Medicine
Official 2016 Collection
School of Public Health Publications
School of Biomedical Sciences Publications
 
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