The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking

Li, Jin, Cui, Yue, Wu, Karen, Liu, Bing, Zhang, Yun, Wang, Chao and Jiang, Tianzi (2015) The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking. NeuroImage, 117 184-190. doi:10.1016/j.neuroimage.2015.05.033

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Author Li, Jin
Cui, Yue
Wu, Karen
Liu, Bing
Zhang, Yun
Wang, Chao
Jiang, Tianzi
Title The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking
Formatted title
The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking
Journal name NeuroImage   Check publisher's open access policy
ISSN 1095-9572
1053-8119
Publication date 2015-08-15
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2015.05.033
Open Access Status File (Author Post-print)
Volume 117
Start page 184
End page 190
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Novelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine–NS relationship. Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure.
Keyword Novelty seeking
Surface area
Cortical thickness
Insula
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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