Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease

Iyer, Abishek, Brown, Lindsay, Whitehead, Jonathan P., Prins, Johannes B. and Fairlie, David P. (2015) Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease. The FASEB Journal, . doi:10.1096/fj.15-271155 fj.15-271155

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Author Iyer, Abishek
Brown, Lindsay
Whitehead, Jonathan P.
Prins, Johannes B.
Fairlie, David P.
Title Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease
Journal name The FASEB Journal   Check publisher's open access policy
ISSN 0892-6638
1530-6860
Publication date 2015-06-11
Year available 2015
Sub-type Article (original research)
DOI 10.1096/fj.15-271155 fj.15-271155
Total pages 14
Place of publication Bethesda, MD United States
Publisher Federation of American Societies for Experimental Biology
Collection year 2016
Language eng
Formatted abstract
The growth and survival of multicellular organisms depend upon their abilities to acquire and metabolize nutrients, efficiently store and harness energy, and sense and fight infection. Systems for sensing and using nutrients have consequently coevolved alongside systems for sensing and responding to danger signals, including pathogens, and share many of the same cell signaling proteins and networks. Diets rich in carbohydrates and fats can overload these systems, leading to obesity, metabolic dysfunction, impaired immunity, and cardiovascular disease. Excessive nutrient intake promotes adiposity, typically altering adipocyte function and immune cell distribution, both of which trigger metabolic dysfunction. Here, we discuss novel mechanistic links between metabolism and immunity that underlie metabolic dysfunction in obesity. We aim to stimulate debate about how the endocrine and immune systems are connected through autocrine, paracrine, and neuroendocrine signaling in sophisticated networks that are only now beginning to be resolved. Understanding the expression and action of signaling proteins, together with modulating their receptors or pattern recognition using agonists or antagonists, will enable rational intervention in immunometabolism that may lead to novel treatments for obesity and metabolic dysfunction.—Iyer, A., Brown, L., Whitehead, J. P., Prins, J. B., Fairlie, D. P. Nutrient and immune sensing are obligate pathways in metabolism, immunity, and diseas
Keyword Macrophage
Toll like receptors
Inflammation
Obesity
Diabetes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 21 Jul 2015, 15:44:16 EST by Susan Allen on behalf of Institute for Molecular Bioscience