Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells

Zhou, Fang, Zhang, Guang-Xian and Rostami, Abdolmohamad (2015) Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells. Immunologic Research, 64 1: 73-81. doi:10.1007/s12026-015-8676-7


Author Zhou, Fang
Zhang, Guang-Xian
Rostami, Abdolmohamad
Title Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells
Formatted title
Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells
Journal name Immunologic Research   Check publisher's open access policy
ISSN 1559-0755
0257-277X
Publication date 2015-06-26
Sub-type Article (original research)
DOI 10.1007/s12026-015-8676-7
Volume 64
Issue 1
Start page 73
End page 81
Total pages 9
Place of publication Totowa, NJ United States
Publisher Humana Press
Collection year 2016
Language eng
Formatted abstract
CD4+ memory T cells play an important role in induction of autoimmunity and chronic inflammatory responses; however, regulatory mechanisms of CD4+ memory T cell-mediated inflammatory responses are poorly understood. Here we show that apoptotic cell-treated dendritic cells inhibit development and differentiation of CD4+ effector memory T cells in vitro and in vivo. Simultaneously, intravenous transfer of apoptotic T cell-induced tolerogenic dendritic cells can block development of experimental autoimmune encephalomyelitis (EAE), an inflammatory disease of the central nervous system in C57 BL/6J mouse. Our results imply that it is effector memory CD4+ T cells, not central memory CD4+ T cells, which play a major role in chronic inflammatory responses in mice with EAE. Intravenous transfer of tolerogenic dendritic cells induced by apoptotic T cells leads to immune tolerance by specifically blocking development of CD4+ effector memory T cells compared with results of EAE control mice. These results reveal a new mechanism of apoptotic cell-treated dendritic cell-mediated immune tolerance in vivo.
Keyword Dendritic cell
Immune tolerance
Immunotherapy
Memory T cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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