The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges

Wortmann, Andreas, He, Yaowu, Deryugina, Elena I., Quigley, James P. and Hooper, John D. (2009) The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges. IUBMB Life, 61 7: 723-730. doi:10.1002/iub.198


Author Wortmann, Andreas
He, Yaowu
Deryugina, Elena I.
Quigley, James P.
Hooper, John D.
Title The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges
Journal name IUBMB Life   Check publisher's open access policy
ISSN 1521-6543
1521-6551
Publication date 2009
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/iub.198
Open Access Status
Volume 61
Issue 7
Start page 723
End page 730
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract In the last few years dysregulated expression of the cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer. Here we summarize what is known about CDCP1 including its structural features, expression in normal and cancerous tissues, and the in vitro experiments and studies in animal models that have provided the key insights into its potential role in tumor formation and metastasis in humans. We conclude by high-lighting opportunities and challenges in targeting CDCP1 in cancer.
Keyword Cancer
CDCP1
Integrin
Leukemia
Src
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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Created: Mon, 20 Jul 2015, 12:35:14 EST by Joanne PRESTON on behalf of Mater Research Institute-UQ