Heritability analysis of surface-based cortical thickness estimation on a large twin cohort

Shen, Kaikai, Dore, Vincent, Rose, Stephen, Fripp, Jurgen, McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Thompson, Paul M., Wright, Margaret J. and Salvado, Olivier (2015). Heritability analysis of surface-based cortical thickness estimation on a large twin cohort. In: Medical Imaging 2015: Image Processing. Medical Imaging 2015: Image Processing, Orlando, Florida, United States, (). Feb 24-26, 2015. doi:10.1117/12.2081677

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Author Shen, Kaikai
Dore, Vincent
Rose, Stephen
Fripp, Jurgen
McMahon, Katie L.
de Zubicaray, Greig I.
Martin, Nicholas G.
Thompson, Paul M.
Wright, Margaret J.
Salvado, Olivier
Title of paper Heritability analysis of surface-based cortical thickness estimation on a large twin cohort
Conference name Medical Imaging 2015: Image Processing
Conference location Orlando, Florida, United States
Conference dates Feb 24-26, 2015
Convener S├ębastien Ourselin
Proceedings title Medical Imaging 2015: Image Processing   Check publisher's open access policy
Journal name Proceedings of SPIE - International Society for Optical Engineering   Check publisher's open access policy
Place of Publication Bellingham, WA United States
Publisher SPIE
Publication Year 2015
Year available 2015
Sub-type Fully published paper
DOI 10.1117/12.2081677
Open Access Status File (Publisher version)
ISBN 9781628415032
ISSN 0277-786X
Volume 9413
Total pages 8
Collection year 2016
Language eng
Abstract/Summary The aim of this paper is to assess the heritability of cerebral cortex, based on measurements of grey matter (GM) thickness derived from structural MR images (sMRI). With data acquired from a large twin cohort (328 subjects), an automated method was used to estimate the cortical thickness, and EM-ICP surface registration algorithm was used to establish the correspondence of cortex across the population. An ACE model was then employed to compute the heritability of cortical thickness. Heritable cortical thickness measures various cortical regions, especially in frontal and parietal lobes, such as bilateral postcentral gyri, superior occipital gyri, superior parietal gyri, precuneus, the orbital part of the right frontal gyrus, right medial superior frontal gyrus, right middle occipital gyrus, right paracentral lobule, left precentral gyrus, and left dorsolateral superior frontal gyrus.
Keyword Imaging genetics
Structural MRI
Heritability
Cortical thickness analysis
Gray matter
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ

 
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