Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation

Roura, Eugeni, Aldayyani, Asya, Thavaraj, Pridhuvi, Prakash, Sangeeta, Greenway, Delma, Thomas, Walter G., Meyerhof, Wolfgang, Roudnitzky, Natacha and Foster, Simon R. (2015) Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation. Chemical Senses, 40 6: 427-435. doi:10.1093/chemse/bjv024


Author Roura, Eugeni
Aldayyani, Asya
Thavaraj, Pridhuvi
Prakash, Sangeeta
Greenway, Delma
Thomas, Walter G.
Meyerhof, Wolfgang
Roudnitzky, Natacha
Foster, Simon R.
Title Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation
Journal name Chemical Senses   Check publisher's open access policy
ISSN 1464-3553
0379-864X
Publication date 2015-07-06
Year available 2015
Sub-type Article (original research)
DOI 10.1093/chemse/bjv024
Volume 40
Issue 6
Start page 427
End page 435
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Abstract The human population displays high variation in taste perception. Differences in individual taste sensitivity may also impact on nutrient intake and overall appetite. A well-characterized example is the variable perception of bitter compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC), which can be accounted for at the molecular level by polymorphic variants in the specific type 2 taste receptor (TAS2R38). This phenotypic variation has been associated with influencing dietary preference and other behaviors, although the generalization of PROP/PTC taster status as a predictor of sensitivity to other tastes is controversial. Here, we proposed that the taste sensitivities of different bitter compounds would be correlated only when they activate the same bitter taste receptor. Thirty-four volunteers were exposed to 8 bitter compounds that were selected based on their potential to activate overlapping and distinct repertoires of TAS2Rs. Taste intensity ratings were evaluated using the general Labeled Magnitude Scale. Our data demonstrate a strong interaction between the intensity for bitter substances when they activate common TAS2Rs. Consequently, PROP/PTC sensitivity was not a reliable predictor of general bitter sensitivity. In addition, our findings provide a novel framework to predict taste sensitivity based on their specific T2R activation profile.
Keyword Bitter taste
GLMS
Hypertaster
Hypotaster
TAS2R
PROP
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 19 Jul 2015, 00:19:26 EST by Sangeeta Prakash on behalf of School of Agriculture and Food Sciences