Dscam2 affects visual perception in Drosophila melanogaster

Bosch, Danny S., van Swinderen, Bruno and Millard, S. Sean (2015) Dscam2 affects visual perception in Drosophila melanogaster. Frontiers in Behavioral Neuroscience, 9 June: 1-13. doi:10.3389/fnbeh.2015.00149

Author Bosch, Danny S.
van Swinderen, Bruno
Millard, S. Sean
Title Dscam2 affects visual perception in Drosophila melanogaster
Formatted title
Dscam2 affects visual perception in Drosophila melanogaster
Journal name Frontiers in Behavioral Neuroscience   Check publisher's open access policy
ISSN 1662-5153
Publication date 2015-06-09
Year available 2015
Sub-type Article (original research)
DOI 10.3389/fnbeh.2015.00149
Open Access Status DOI
Volume 9
Issue June
Start page 1
End page 13
Total pages 13
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2016
Language eng
Formatted abstract
Dscam2, a cell surface protein that mediates cellular repulsion, plays a crucial role in the development of the Drosophila melanogaster visual system. Dscam2 generates boundaries between neighboring modules in the fly optic lobe; in Dscam2 mutants this visual system modularity is compromised. Although developmental wiring defects have been well described in the Dscam2 mutant, behavioral consequences have not been investigated. To address this, we examined the visual behavior of Dscam2 mutant flies. Using a phototaxis assay, we ascertained that these flies are not blind, but have a reduced phototaxic response. Through population-based and single fly optomotor assays, we found that Dscam2 mutant flies can track motion but that their response is opposite to control flies under defined experimental conditions. In a fixation paradigm, which allows tethered flies to control the angular position of a visual stimulus, mutant flies' responses were diametrically opposed to those seen in control flies. These data suggest that modest changes in the modularity of the fly visual system in the Dscam2 mutant can dramatically change the perception of specific visual cues and modify behavior.
Keyword Dscam
Visual perception
Behavioral assay
Motion detection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 17 Jul 2015, 16:13:32 EST by Susan Day on behalf of School of Biomedical Sciences