δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

Jin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015) δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 1811: 1-8. doi:10.1098/rspb.2015.0817


Author Jin, Ai-Hua
Israel, Mathilde R.
Inserra, Marco
Smith, Jennifer J.
Lewis, Richard J.
Alewood, Paul F.
Vetter, Irina
Dutertre, Sebastien
Title δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
Journal name Proceedings of the Royal Society B: Biological Sciences   Check publisher's open access policy
ISSN 0962-8452
1471-2954
Publication date 2015-07-08
Year available 2015
Sub-type Article (original research)
DOI 10.1098/rspb.2015.0817
Open Access Status DOI
Volume 282
Issue 1811
Start page 1
End page 8
Total pages 8
Place of publication London, United Kingdom
Publisher The Royal Society Publishing
Collection year 2016
Language eng
Formatted abstract
Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target Kv and Nav channels. As part of this envenomation strategy, delta-conotoxins are potent ichtyotoxins that enhance Nav channel function. delta-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active delta-conotoxin characterized from a vermivorous cone snail (Conus suturatus). SuVIA is equipotent at hNaV1.3, hNaV1.4 and hNaV1.6 with EC50s in the low nanomolar range. SuVIA also increased peak hNaV1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from -15 mV to -25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that delta-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that delta-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.
Keyword Conotoxin
Defence
Molecular Evolution
Predation
Venom
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes In Press

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 17 Jul 2015, 14:44:46 EST by Susan Allen on behalf of Institute for Molecular Bioscience