Cytomegalovirus MHC class I homologues and natural killer

Farrell, Helen, Degli-Esposti, Mariapia, Densley, Eloise, Cretney, Erika, Smyth, Mark and Davis-Poynter, Nicholas (2000-04) Cytomegalovirus MHC class I homologues and natural killer. Microbes and Infection, 2 5: 521-532.

Document type:	Journal Article
Collection:	Clinical Medical Virology Centre Publications

Author(s)	Farrell, Helen Degli-Esposti, Mariapia Densley, Eloise Cretney, Erika Smyth, Mark Davis-Poynter, Nicholas
Title	Cytomegalovirus MHC class I homologues and natural killer
Journal name	Microbes and Infection
Publication date	2000-04
Sub-type	Review of research - research literature review (NOT book review
Volume number	2
Issue number	5
ISSN	1286-4579
Start page	521
End page	532
Total pages	12
Place of publication	Paris ; New York
Publisher	Elsevier
Language	eng
Subject	060506 Virology
Abstract	Viruses that establish a persistent infection with their host have evolved numerous strategies to evade the immune system. Consequently, they are useful tools to dissect the complex cellular processes that comprise the immune response. Rapid progress has been made in recent years in defining the role of cellular MHC class I molecules in regulating the response of natural killer (NK) cells. Concomitantly, the roles of the MHC class I homologues encoded by human and mouse cytomegaloviruses in evading or subverting NK cell responses has received considerable interest. This review discusses the results from a number of studies that have pursued the biological function of the viral MHC class I homologues. Based on the evidence from these studies, hypotheses for the possible role of these intriguing molecules are presented. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Keyword(s)	Immunology Microbiology Virology Cytomegalovirus Immune Evasion Mhc Class I Proteins Nk Cells Receptor Ly-49a Recognizes Murine Cytomegalovirus Inhibitory Receptor Nk Cells Endoplasmic-reticulum Gene-complex T-cell Myelomonocytic Cells Viral Interference Immune-responses