Neurocognitive effects following cranial irradiation for brain metastases

Pinkham, M. B., Sanghera, P., Wall, G. K., Dawson, B. D. and Whitfield, G. A. (2015) Neurocognitive effects following cranial irradiation for brain metastases. Clinical Oncology, 27 11: 630-639. doi:10.1016/j.clon.2015.06.005

Author Pinkham, M. B.
Sanghera, P.
Wall, G. K.
Dawson, B. D.
Whitfield, G. A.
Title Neurocognitive effects following cranial irradiation for brain metastases
Journal name Clinical Oncology   Check publisher's open access policy
ISSN 1433-2981
Publication date 2015-06-25
Sub-type Article (original research)
DOI 10.1016/j.clon.2015.06.005
Open Access Status Not Open Access
Volume 27
Issue 11
Start page 630
End page 639
Total pages 10
Place of publication London, United Kingdom
Publisher W. B. Saunders
Collection year 2016
Language eng
Abstract About 90% of patients with brain metastases have impaired neurocognitive function at diagnosis and up to two-thirds will show further declines within 2–6 months of whole brain radiotherapy. Distinguishing treatment effects from progressive disease can be challenging because the prognosis remains poor in many patients. Omitting whole brain radiotherapy after local therapy in good prognosis patients improves verbal memory at 4 months, but the effect of higher intracranial recurrence and salvage therapy rates on neurocognitive function beyond this time point is unknown. Hippocampal-sparing whole brain radiotherapy and postoperative stereotactic radiosurgery are investigational techniques intended to reduce toxicity. Here we describe the changes that can occur and review technological, pharmacological and practical approaches used to mitigate their effect in clinical practice.
Keyword Brain metastases
Neurocognitive function
Quality of life
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article in press corrected proof.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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