Melanoma survival is superior in females across all tumour stages but is influenced by age

Khosrotehrani, Kiarash, Dasgupta, Paramita, Byrom, Lisa, Youlden, Danny R., Baade, Peter D. and Green, Adele C. (2015) Melanoma survival is superior in females across all tumour stages but is influenced by age. Archives of Dermatological Research, 307 8: 731-740. doi:10.1007/s00403-015-1585-8

Author Khosrotehrani, Kiarash
Dasgupta, Paramita
Byrom, Lisa
Youlden, Danny R.
Baade, Peter D.
Green, Adele C.
Title Melanoma survival is superior in females across all tumour stages but is influenced by age
Journal name Archives of Dermatological Research   Check publisher's open access policy
ISSN 1432-069X
Publication date 2015-06-24
Sub-type Article (original research)
DOI 10.1007/s00403-015-1585-8
Open Access Status Not Open Access
Volume 307
Issue 8
Start page 731
End page 740
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2016
Language eng
Formatted abstract
Among patients with invasive melanoma, females are known to have higher survival than males globally. However, this survival advantage has not been explored in thin melanomas, the most common form of the disease. In addition, it is unclear if this advantage is true across all age groups. We aimed to compare melanoma survival between males and females by clinical stage and within age groups. Melanomas from 1995 to 2008 were extracted from the Queensland Cancer Registry and the Surveillance, Epidemiology, and End Results (SEER) Program, and melanoma-specific deaths were ascertained up to 2011. Flexible parametric survival models compared survival between groups. The Queensland cohort of 28,979 patients experienced 1712 melanoma deaths and the SEER cohort of 57,402 patients included 6929 melanoma deaths. Survival rates were in favour of females across nearly all tumour stages, including thin invasive tumours in both cohorts after adjusting for demographic and clinical factors [odds ratio (OR) death female:male for stage I melanoma = 0.64 in Queensland; and OR = 0.79 in the US, both P < 0.001]. The sex influence on survival interacted with age categories. In particular, the survival advantage was inconsistent in females with stage I melanoma aged under 60. Females with melanoma have a survival advantage over males including in stage I melanomas. However, this advantage is dependent on age at diagnosis, suggesting an underlying biological mechanism influenced by age that exists from the very early stages of the disease.
Keyword Gender
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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