Subcortical Glutamate Mediates the Reduction of Short-Range Functional Connectivity with Age in a Developmental Cohort

Ghisleni, Carmen, Bollmann, Steffen, Poil, Simon-Shlomo, Brandeis, Daniel, Martin, Ernst, Michels, Lars, O’Gorman, Ruth L. and Klaver, Peter (2015) Subcortical Glutamate Mediates the Reduction of Short-Range Functional Connectivity with Age in a Developmental Cohort. The Journal of Neuroscience, 35 22: 8433-8441. doi:10.1523/JNEUROSCI.4375-14.2015

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Author Ghisleni, Carmen
Bollmann, Steffen
Poil, Simon-Shlomo
Brandeis, Daniel
Martin, Ernst
Michels, Lars
O’Gorman, Ruth L.
Klaver, Peter
Title Subcortical Glutamate Mediates the Reduction of Short-Range Functional Connectivity with Age in a Developmental Cohort
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2015-03-06
Year available 2015
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4375-14.2015
Open Access Status File (Publisher version)
Volume 35
Issue 22
Start page 8433
End page 8441
Total pages 9
Place of publication Washington, DC United States
Publisher Society for Neuroscience
Collection year 2016
Language eng
Formatted abstract
Marked changes in brain physiology and structure take place between childhood and adulthood, including changes in functional connectivity and changes in the balance between main excitatory and inhibitory neurotransmitters glutamate (Glu) and GABA. The balance of these neurotransmitters is thought to underlie neural activity in general and functional connectivity networks in particular, but so far no studies have investigated the relationship between human development related differences in these neurotransmitters and concomitant changes in functional connectivity. GABA+/H2O and Glu/H2O levels were acquired in a group of healthy children, adolescents, and adults in a subcortical (basal ganglia) region, as well as in a frontal region in adolescents and adults. Our results showed higher GABA+/ Glu with age in both the subcortical and the frontal voxel, which were differentially associated with significantly lower Glu/H2O with age in the subcortical voxel and by significantly higher GABA+/H2O with age in the frontal voxel. Using a seed-to-voxel analysis, we were further able to show that functional connectivity between the putamen (seed) and other subcortical structures was lower with age. Lower subcortical Glu/H2O with age mediated the lower connectivity in the dorsal putamen. Based on these results, and the potential role of Glu in synaptic pruning, we suggest that lower Glu mediates a reduction of local connectivity during human development.
Keyword Glutamate
Functional Connectivity
Development
Functional connectivity
Magnetic resonance spectroscopy
Working memory
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Centre for Advanced Imaging Publications
 
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Created: Thu, 09 Jul 2015, 13:56:13 EST by Steffen Bollmann on behalf of Centre for Advanced Imaging