Therapeutic conotoxins: a US patent literature survey

Durek, Thomas and Craik, David J. (2015) Therapeutic conotoxins: a US patent literature survey. Expert Opinion in Therapeutic Patents, 25 10: 1159-1173. doi:10.1517/13543776.2015.1054095


Author Durek, Thomas
Craik, David J.
Title Therapeutic conotoxins: a US patent literature survey
Journal name Expert Opinion in Therapeutic Patents   Check publisher's open access policy
ISSN 1354-3776
1744-7674
Publication date 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/13543776.2015.1054095
Volume 25
Issue 10
Start page 1159
End page 1173
Total pages 15
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Formatted abstract
Introduction: Conotoxins are a large family of bioactive peptides derived from cone snail venom. They target specific classes of ion channels and other membrane proteins and may have therapeutic value, primarily in the management of pain.

Areas covered: The authors surveyed the US patent literature covering conotoxins, and their potential therapeutic applications. They describe the various subclasses of conotoxins that are the subject of current patent applications and their therapeutic indications. Limitations that may preclude broader application of these molecules are discussed and strategies for overcoming these limitations are presented.

Expert opinion: Despite more than 25 years of intense global conotoxin research, only one molecule has successfully reached the market. Several other conotoxin-derived candidates failed in clinical trials, indicating that ‘from the bench into the clinic’ translation has been more difficult than originally anticipated. Nevertheless, we are optimistic that the potent activities of these molecules and the potential for improving their biopharmaceutical properties may lead to next-generation drug candidates with favorable pharmacological properties.

Keyword Cone snail venom
Conopeptide
Drugs
Ion channel
Pain
Peptide
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 09 Jul 2015, 10:17:21 EST by Susan Allen on behalf of Institute for Molecular Bioscience