Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology

Sepehrband, Farshid, Clark, Kristi A., Ullmann, Jeremy F. P., Kurniawan, Nyoman D., Leanage, Gayeshika, Reutens, David C. and Yang, Zhengyi (2015) Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology. Human Brain Mapping, 36 9: 3687-3702. doi:10.1002/hbm.22872


Author Sepehrband, Farshid
Clark, Kristi A.
Ullmann, Jeremy F. P.
Kurniawan, Nyoman D.
Leanage, Gayeshika
Reutens, David C.
Yang, Zhengyi
Title Brain tissue compartment density estimated using diffusion-weighted MRI yields tissue parameters consistent with histology
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1097-0193
1065-9471
Publication date 2015-06-11
Sub-type Article (original research)
DOI 10.1002/hbm.22872
Open Access Status
Volume 36
Issue 9
Start page 3687
End page 3702
Total pages 16
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons
Collection year 2016
Language eng
Formatted abstract
We examined whether quantitative density measures of cerebral tissue consistent with histology can be obtained from diffusion magnetic resonance imaging (MRI). By incorporating prior knowledge of myelin and cell membrane densities, absolute tissue density values were estimated from relative intracellular and intraneurite density values obtained from diffusion MRI. The NODDI (neurite orientation distribution and density imaging) technique, which can be applied clinically, was used. Myelin density estimates were compared with the results of electron and light microscopy in ex vivo mouse brain and with published density estimates in a healthy human brain. In ex vivo mouse brain, estimated myelin densities in different subregions of the mouse corpus callosum were almost identical to values obtained from electron microscopy (diffusion MRI: 42 ± 6%, 36 ± 4%, and 43 ± 5%; electron microscopy: 41 ± 10%, 36 ± 8%, and 44 ± 12% in genu, body and splenium, respectively). In the human brain, good agreement was observed between estimated fiber density measurements and previously reported values based on electron microscopy. Estimated density values were unaffected by crossing fibers.
Keyword Diffusion-weighted MRI
NODDI
DTI
Tissue compartment density
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Early view.

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 07 Jul 2015, 05:10:12 EST by System User on behalf of Scholarly Communication and Digitisation Service