Increasing Clozapine Dispensing Trends in Queensland, Australia 2004–2013

Forrester, T., Siskind, D., Winckel, K., Wheeler, A. and Hollingworth, S. (2015) Increasing Clozapine Dispensing Trends in Queensland, Australia 2004–2013. Pharmacopsychiatry, 48 4-5: 164-169. doi:10.1055/s-0035-1554713

Author Forrester, T.
Siskind, D.
Winckel, K.
Wheeler, A.
Hollingworth, S.
Title Increasing Clozapine Dispensing Trends in Queensland, Australia 2004–2013
Journal name Pharmacopsychiatry   Check publisher's open access policy
ISSN 0176-3679
Publication date 2015-05-19
Year available 2015
Sub-type Article (original research)
DOI 10.1055/s-0035-1554713
Volume 48
Issue 4-5
Start page 164
End page 169
Total pages 6
Place of publication Stuttgart, Germany
Publisher Georg Thieme Verlag
Collection year 2016
Language eng
Formatted abstract
Introduction: Clozapine is the most effective treatment for treatment-resistant schizophrenia but its use is suboptimal.

Methods: Clozapine dispensing data from Queensland, Australia were extracted (2004–2013). The number of people dispensed clozapine each year and mean maintenance doses were calculated. The 18-week and 5-year cessation and treatment interruption rates were calculated using Kaplan-Meier analysis.

Results: Clozapine dispensings increased 36.4% (p<0.001) from 44 to 60 people per 100 000. This was estimated as 8.3% of people with schizophrenia and 33.3% of people with treatment resistant schizophrenia dispensed clozapine in 2013. Mean maintenance dose did not significantly change (364–399 mg) over 5 years of treatment. One in 7 (14.2%) people ceased within the first 3 weeks. 3-quarters (72.7%) reached maintenance therapy. The 5-year actuarial estimate of the proportion of people a) dispensed clozapine was 0.610 (S.E. 0.011) and b) with an interruption to treatment was 0.422 (S.E. 0.013).

Discussion: The number of patients being dispensed clozapine increased between 2004 and 2013 but clozapine is still underused. Increased use combined with continued monitoring for adverse effects will improve quality use of clozapine.
Keyword Antipsychotic
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
School of Pharmacy Publications
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