Impaired T-cell function in B-cell lymphoma: a direct consequence of events at the immunological synapse?

Roufaiel, Marian Nassef Kadry Naguib, Wells, James W. and Steptoe, Raymond J. (2015) Impaired T-cell function in B-cell lymphoma: a direct consequence of events at the immunological synapse?. Frontiers in Immunology, 6 JUN: 258.1-258.10. doi:10.3389/fimmu.2015.00258


Author Roufaiel, Marian Nassef Kadry Naguib
Wells, James W.
Steptoe, Raymond J.
Title Impaired T-cell function in B-cell lymphoma: a direct consequence of events at the immunological synapse?
Journal name Frontiers in Immunology   Check publisher's open access policy
ISSN 1664-3224
Publication date 2015-06-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fimmu.2015.00258
Open Access Status DOI
Volume 6
Issue JUN
Start page 258.1
End page 258.10
Total pages 10
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2016
Language eng
Formatted abstract
Tumors can escape immune destruction through the development of antigen loss variants and loss of antigen processing/presentation pathways, thereby rendering them invisible to T cells. Alternatively, mechanisms of peripheral T-cell tolerance that would normally be important for protection from the development of autoimmunity may also be co-opted to (i) generate an immuno-inhibitory tumor environment, (ii) promote development of regulatory cell populations, or (iii) cell-intrinsically inactivate tumor-specific T cells. Emerging evidence suggests that T-cell function is impaired in hematological malignancies, which may manifest from cognate interactions between T cells and the tumor. The immunological synapse forms the cognate T-cell and antigen-presenting cell interaction and is the site where key signalling events, including those delivered by co-inhibitory receptors, that determine the fate of T cells occur. Here, we review evidence that events at the immune synapse between T cells and malignant B cells and alterations in immune synapse function may contribute to loss of T-cell function in B-cell malignancies.
Keyword Lymphoma
Immunological synapse
T-cell tolerance
T-cell function
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
 
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Created: Thu, 02 Jul 2015, 11:50:32 EST by Anthony Yeates on behalf of UQ Diamantina Institute