Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta

Phan, N.T., Cabot, P.J., Wallwork, B.D., Cervin, A.U. and Panizza, B.J. (2015) Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta. Journal of Laryngology and Otology, 129 S3: S2-S7. doi:10.1017/S0022215115001322


Author Phan, N.T.
Cabot, P.J.
Wallwork, B.D.
Cervin, A.U.
Panizza, B.J.
Title Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta
Journal name Journal of Laryngology and Otology   Check publisher's open access policy
ISSN 1748-5460
0022-2151
Publication date 2015-06-15
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1017/S0022215115001322
Open Access Status
Volume 129
Issue S3
Start page S2
End page S7
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2016
Language eng
Formatted abstract
Background: Chronic rhinosinusitis is characterised by persistent inflammation of the sinonasal mucosa. Multiple pathophysiological mechanisms are likely to exist. Previous research has focused predominantly on T-helper type cytokines to highlight the inflammatory mechanisms. However, proteins such as nuclear factor kappa B and transforming growth factor beta are increasingly recognised to have important roles in sinonasal inflammation and tissue remodelling.
      Objective: This review article explores the roles of T-helper type cytokines, nuclear factor kappa B and transforming growth factor beta in the pathophysiological mechanisms of chronic rhinosinusitis. An understanding of these mechanisms will allow for better identification and classification of chronic rhinosinusitis endotypes, and, ultimately, improved therapeutic strategies.
Keyword Sinusitis
Cytokines
Nf-kappa B
Transforming growth factor beta
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Early view of article.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
School of Pharmacy Publications
 
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