Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle

Ferreira de Camargo, Gregorio Miguel, Porto-Neto, Laercio R., Kelly, Matthew J., Bunch, Rowan J., McWilliam, Sean M., Tonhati, Humberto, Lehnert, Sigrid A., Fortes, Marina R. S. and Moore, Stephen S. (2015) Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle. BMC Genomics, 16 1: 384.1-384.10. doi:10.1186/s12864-015-1595-0


Author Ferreira de Camargo, Gregorio Miguel
Porto-Neto, Laercio R.
Kelly, Matthew J.
Bunch, Rowan J.
McWilliam, Sean M.
Tonhati, Humberto
Lehnert, Sigrid A.
Fortes, Marina R. S.
Moore, Stephen S.
Title Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle
Journal name BMC Genomics   Check publisher's open access policy
ISSN 1471-2164
Publication date 2015-05-15
Sub-type Article (original research)
DOI 10.1186/s12864-015-1595-0
Open Access Status DOI
Volume 16
Issue 1
Start page 384.1
End page 384.10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Formatted abstract
Background: Previous genome-wide association analyses identified QTL regions in the X chromosome for percentage of normal sperm and scrotal circumference in Brahman and Tropical Composite cattle. These traits are important to be studied because they are indicators of male fertility and are correlated with female sexual precocity and reproductive longevity. The aim was to investigate candidate genes in these regions and to identify putative causative mutations that influence these traits. In addition, we tested the identified mutations for female fertility and growth traits.

Results: Using a combination of bioinformatics and molecular assay technology, twelve non-synonymous SNPs in eleven genes were genotyped in a cattle population. Three and nine SNPs explained more than 1% of the additive genetic variance for percentage of normal sperm and scrotal circumference, respectively. The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference. One SNP in TEX11 was explained ~13% of the additive genetic variance for scrotal circumference at 12 months. The tested SNP were also associated with weight measurements, but not with female fertility traits.

Conclusions: The strong association of SNPs located in X chromosome genes with male fertility traits validates the QTL. The implicated genes became good candidates to be used for genetic evaluation, without detrimentally influencing female fertility traits.
Keyword Bos taurus indicus
Non-synonymous SNP
Scrotal circumference
Sperm morphology
X chromosome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 25 Jun 2015, 01:18:42 EST by Anthony Yeates on behalf of School of Chemistry & Molecular Biosciences