Genetic ablation of placental sinusoidal trophoblast giant cells causes fetal growth restriction and embryonic lethality

Outhwaite, J. E., McGuire, V. and Simmons, D. G. (2015) Genetic ablation of placental sinusoidal trophoblast giant cells causes fetal growth restriction and embryonic lethality. Placenta, 36 8: 951-955. doi:10.1016/j.placenta.2015.05.013


Author Outhwaite, J. E.
McGuire, V.
Simmons, D. G.
Title Genetic ablation of placental sinusoidal trophoblast giant cells causes fetal growth restriction and embryonic lethality
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2015-08
Sub-type Article (original research)
DOI 10.1016/j.placenta.2015.05.013
Open Access Status Not yet assessed
Volume 36
Issue 8
Start page 951
End page 955
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
A specialized subtype of trophoblast giant cells (TGCs) line the torturous sinusoids of the murine placental labyrinth, and can be distinguished from most other TGCs by the expression of Ctsq. We generated a transgenic mouse line expressing Cre recombinase from the Ctsq promoter. Crosses with Cre-inducible tdTomato reporter mice indicated Cre activity was restricted to the sinusoidal TGCs of the labyrinth, as well as the recently characterized channel TGCs. When crossed with Cre-inducible DTA transgenic mice, ablation of sinusoidal TGCs was achieved in double transgenic embryos, resulting in fetal growth restriction by E16.5, and embryonic lethality by term.
Keyword Cathepsin Q
Cre recombinase
Diphtheria toxin
Placenta
Sinusoidal trophoblast giant cell
Transgenic mouse
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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