Current versus lifetime depression, APOE variation, and their interaction on cognitive performance in younger and older adults

Luciano, Michelle, Pujals, Ana Maria Fernandez, Marioni, Riccardo E, Campbell, Archie, Hayward, Caroline, MacIntyre, Donald J, Porteous, David J, McIntosh, Andrew M and Deary, Ian J (2015) Current versus lifetime depression, APOE variation, and their interaction on cognitive performance in younger and older adults. Psychosomatic Medicine, 77 5: 480-492. doi:10.1097/PSY.0000000000000190


Author Luciano, Michelle
Pujals, Ana Maria Fernandez
Marioni, Riccardo E
Campbell, Archie
Hayward, Caroline
MacIntyre, Donald J
Porteous, David J
McIntosh, Andrew M
Deary, Ian J
Title Current versus lifetime depression, APOE variation, and their interaction on cognitive performance in younger and older adults
Journal name Psychosomatic Medicine   Check publisher's open access policy
ISSN 1534-7796
0033-3174
Publication date 2015-06
Year available 2015
Sub-type Article (original research)
DOI 10.1097/PSY.0000000000000190
Volume 77
Issue 5
Start page 480
End page 492
Total pages 13
Place of publication Philadelphia, United States
Publisher Lippincott Williams and Wilkins
Collection year 2016
Language eng
Subject 2738 Psychiatry and Mental health
3202 Applied Psychology
1201 Architecture
3204 Developmental and Educational Psychology
Formatted abstract
Objective: An interaction effect of depressive symptoms and APOE e4 allele status on cognitive decline has been shown in old age: e4 allele carriers with more depressive symptoms have faster cognitive decline than those with either depression or the e4 allele. We test this interaction effect on four cognitive domains, using a clinical depression measure comparing current versus lifetime depression.

Methods: 14,379 individuals aged 18 to 59 years, and 3944 individuals aged 60 to 94 years from the Generation Scotland: Scottish Family Health Study participated. Linear-mixed models—accounting for participant relatedness and demographic and health indices—tested for effects of depression and APOE on cognitive abilities.

Results: There was no interaction between depression and APOE on cognition (p > .05). Current depression was associated with poorer speed (in both groups) and memory (18- to 59-year-olds); differences ranged from 0.01 to 0.03 standard deviation [SD]. For lifetime depression, cognitive performance was lower for digit symbol in younger adults, but higher for vocabulary in both younger (0.03 SD) and older (0.05 SD) adults. A negative effect of the APOE e4 allele on speed and memory was found in the group 60 years and older (effect sizes of 0.04 SD).

Conclusions: The absence of a depression by APOE interaction on cognitive abilities suggests that these synergistic effects only operate at the level of cognitive decline. This implies that it is those biological pathways especially affected by aging that become compromised further by the combined presence of depression and APOE e4 in an individual.
Keyword Structured Clinical Interview for DSM-IV depression
general health questionnaire
processing speed
memory
verbal ability
apolipoprotein E.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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