Cross-sectional and longitudinal lipid determination studies in pregnant women reveal an association between increased maternal LDL cholesterol concentrations and reduced human umbilical vein relaxation

Leiva, A., Salsoso, R., Saez, T., Sanhueza, C., Pardo, F. and Sobrevia, L. (2015) Cross-sectional and longitudinal lipid determination studies in pregnant women reveal an association between increased maternal LDL cholesterol concentrations and reduced human umbilical vein relaxation. Placenta, 36 8: 895-902. doi:10.1016/j.placenta.2015.05.012


Author Leiva, A.
Salsoso, R.
Saez, T.
Sanhueza, C.
Pardo, F.
Sobrevia, L.
Title Cross-sectional and longitudinal lipid determination studies in pregnant women reveal an association between increased maternal LDL cholesterol concentrations and reduced human umbilical vein relaxation
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2015-08-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.placenta.2015.05.012
Volume 36
Issue 8
Start page 895
End page 902
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Introduction

Maternal hypercholesterolemia and hypertriglyceridemia during pregnancy is correlated with fetoplacental endothelial dysfunction and atherosclerotic lesions in fetal arteries. Few studies have reported the distribution of the concentrations of maternal total cholesterol (TCh), lipoprotein cholesterol and triglycerides during pregnancy. Therefore, we determined maternal lipid concentration during pregnancy and established the percentiles over which fetoplacental endothelial dysfunction is observed.

Methods

A lipoprotein profile was determined for 249 pregnant Chilean women in each trimester of pregnancy in cross-sectional and longitudinal lipid determination studies. Distribution percentiles for TCh, high–, low– and very-low–density lipoprotein (HDL, LDL, and vLDL, respectively) cholesterol and triglycerides were estimated. The reactivity of human umbilical vein rings to the calcitonin gene-related peptide (0.1–1000 nmol/L, 5 min) and sodium nitroprusside (10 μmol/L, 5 min) was measured (wire myography) in KCl-preconstricted vessels.

Results

Maternal lipoproteins and triglyceride concentrations increased over time from preconception to the 3rd trimester of pregnancy. Newborn umbilical blood lipoprotein and triglyceride concentrations were lower than those in maternal circulation. Changes in maternal HDL correlated with newborn HDL concentration; however, no correlation between maternal lipoprotein concentrations and newborn weight was found. Maternal TCh and LDL concentrations were inversely correlated with the maximal dilation, but the >75th percentile of maternal TCh and LDL concentrations (>291 and >169 mg/dL, respectively) correlated with reduced calcitonin gene-related peptide sensitivity of the vein rings.

Discussion and conclusion

We identified percentiles for maternal TCh and LDL concentrations over which abnormal endothelium-dependent human fetoplacental vascular response is observed.
Keyword Cholesterol
Triglycerides
Fetal endothelium
Vein reactivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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