Recent advances in physical delivery enhancement of topical drugs

Raphael, A. P., Wright, O. R. L., Benson, Heather A. and Prow, Tarl W. (2015) Recent advances in physical delivery enhancement of topical drugs. Current Pharmaceutical Design, 21 20: 2830-2847. doi:10.2174/1381612821666150428144852


Author Raphael, A. P.
Wright, O. R. L.
Benson, Heather A.
Prow, Tarl W.
Title Recent advances in physical delivery enhancement of topical drugs
Journal name Current Pharmaceutical Design   Check publisher's open access policy
ISSN 1873-4286
1381-6128
Publication date 2015
Sub-type Article (original research)
DOI 10.2174/1381612821666150428144852
Open Access Status Not Open Access
Volume 21
Issue 20
Start page 2830
End page 2847
Total pages 18
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2016
Language eng
Abstract The skin has evolved to resist the penetration of foreign substances and particles. Effective topical drug delivery into and/or through the skin is hindered by these epidermal barriers. A range of physical enhancement methods has been developed to selectively overcome this barrier. This review discusses recent advances in physical drug delivery by broadly separating the techniques into two main areas; indirect and direct approaches. Indirect approaches consist of electrical, vibrational or laser instrumentation that creates pores in the skin followed by application of the drug. Direct approaches consist of mechanical disruption of the epidermis using techniques such as microdermabrasion, biolistic injectors and microneedles. Although, in general, physical techniques are yet to be established in a clinical setting, the potential gains of enhancing delivery of compounds through the skin is of great significance and will no doubt continue to receive much attention.
Keyword Iontophoresis
Microneedles
Microparticles
Needle-free
Sonophoressis
Transdermal drug delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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