Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia

Martin, Andrew K, Robinson, G, Reutens, D and Mowry, B (2015) Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia. Psychiatry Research, 229 1-2: 606-608. doi:10.1016/j.psychres.2015.04.045


Author Martin, Andrew K
Robinson, G
Reutens, D
Mowry, B
Title Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia
Journal name Psychiatry Research   Check publisher's open access policy
ISSN 1872-7123
0165-1781
Publication date 2015-09-30
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.psychres.2015.04.045
Open Access Status Not yet assessed
Volume 229
Issue 1-2
Start page 606
End page 608
Total pages 3
Place of publication Shannon, Clare Ireland
Publisher Elsevier Ireland
Collection year 2016
Language eng
Abstract Schizophrenia is a clinically heterogeneous disorder associated with broad deficits across cognitive domains. As large genomewide association studies uncover the genetic architecture of schizophrenia, the relationship between common genetic variants and clinical and cognitive characteristics will form part of an integrative approach to understanding genetic effects on the clinical phenotype. In the current study, association between common genetic risk variants and clinical and cognitive variables was investigated. Common risk variants were associated with positive symptoms and decision-making ability from the Cambridge Gambling Task with trends in other domains.
Keyword Cognition
Polygene risk scores
Positive symptoms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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