Microbial chemical signaling: A current perspective

Bandara, H. M. H. N., Lam, O. L. T., Jin, L. J. and Samaranayake, Lakshman (2012) Microbial chemical signaling: A current perspective. Critical Reviews in Microbiology, 38 3: 217-249. doi:10.3109/1040841X.2011.652065


Author Bandara, H. M. H. N.
Lam, O. L. T.
Jin, L. J.
Samaranayake, Lakshman
Title Microbial chemical signaling: A current perspective
Journal name Critical Reviews in Microbiology   Check publisher's open access policy
ISSN 1040-841X
1549-7828
Publication date 2012
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/1040841X.2011.652065
Open Access Status
Volume 38
Issue 3
Start page 217
End page 249
Total pages 33
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Abstract Communication among microorganisms is mediated through quorum sensing. The latter is defined as cell-density linked, coordinated gene expression in microbial populations as a response to threshold signal concentrations followed by induction of a synchronized population response. This phenomenon is used by a variety of microbes to optimize their survival in a constantly challenging, dynamic milieu, by correlating individual cellular functions to community-based requirements. The synthesis, secretion, and perception of quorum-sensing molecules and their target response play a pivotal role in quorum sensing and are tightly controlled by complex, multilayered and interconnected signal transduction pathways that regulate diverse cellular functions. Quorum sensing exemplifies interactive social behavior innate to the microbial world that controls features such as, virulence, biofilm maturation, antibiotic resistance, swarming motility, and conjugal plasmid transfer. Over the past two decades, studies have been performed to rationalize bacterial cell-to-cell communication mediated by structurally and functionally diverse small molecules. This review describes the theoretical aspects of cellular and quorum-sensing mechanisms that affect microbial physiology and pathobiology.
Keyword Autoinducer
Bacteria
Cell cell signaling
Fungi
Quorum sensing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Dentistry Publications
 
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Created: Sun, 21 Jun 2015, 16:00:21 EST by Nihal Bandara on behalf of School of Dentistry