Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle

Little, PJ, Neylon, CB, Tkachuk, VA and Bobik, A (1992) Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle. Biochemical and Biophysical Research Communications, 183 2: 694-700. doi:10.1016/0006-291X(92)90538-V


Author Little, PJ
Neylon, CB
Tkachuk, VA
Bobik, A
Title Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 1090-2104
Publication date 1992-03-16
Sub-type Article (original research)
DOI 10.1016/0006-291X(92)90538-V
Volume 183
Issue 2
Start page 694
End page 700
Total pages 7
Language eng
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
Abstract The mechanisms by which endothelin-1 (ET-1) and endothelin-3 (ET-3) stimulate Ca2+ mobilization were investigated in rat aortic smooth muscle cells. Both ET-1 and ET-3 potently stimulated mobilization of Ca2+ from intracellular stores, however only ET-1-stimulated Ca2+ mobilization appeared to occur as a consequence of an elevation in cellular inositol trisphosphate (IP3) concentration. Neomycin, an inhibitor of phospholipase C, inhibited both the increase in [3H]IP3 formation and the mobilization of Ca2+ induced by ET-1, however it did not affect Ca2+ mobilization induced by ET-3. Together these findings indicate that ET-1 stimulates Ca2+ mobilization via an increase in IP3, whereas the effect of ET-3 appears to be mediated by a separate, IP3-independent signalling pathway.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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