Insulin resistance and atherosclerosis

Nigro, Julie, Osman, Narin, Dart, Anthony M. and Little, Peter J. (2006) Insulin resistance and atherosclerosis. Endocrine Reviews, 27 3: 242-259. doi:10.1210/er.2005-0007

Author Nigro, Julie
Osman, Narin
Dart, Anthony M.
Little, Peter J.
Title Insulin resistance and atherosclerosis
Journal name Endocrine Reviews   Check publisher's open access policy
ISSN 0163-769X
Publication date 2006-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1210/er.2005-0007
Open Access Status Not yet assessed
Volume 27
Issue 3
Start page 242
End page 259
Total pages 18
Place of publication Chevy Chase, MD, United States
Publisher The Endocrine Society
Language eng
Abstract The epidemic of obesity in the developed world over the last two decades is driving a large increase in type 2 diabetes and consequentially setting the scene for an impending wave of cardiovascular morbidity and mortality. It is only now being recognized that the major antecedent of type 2 diabetes, insulin resistance with its attendant syndrome, is the major underlying cause of the susceptibility to type 2 diabetes and cardiovascular disease. In metabolic tissues, insulin signaling via the phosphatidylinositol-3-kinase pathway leads to glucose uptake so that in insulin resistance a state of hyperglycemia occurs; other factors such as dyslipidemia and hypertension also arise. In cardiovascular tissues there are two pathways of insulin receptor signaling, one that is predominant in metabolic tissues (mediated by phosphatidylinositol-3- kinase) and another being a growth factor-like pathway (mediated by MAPK); the down-regulation of the former and continued activity of the latter pathway leads to atherosclerosis. This review addresses the metabolic consequences of the insulin resistance syndrome, its relationship with atherosclerosis, and the impact of insulin resistance on processes of atherosclerosis including insulin signaling in cells of the vasculature. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
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