Lipid: extracellular matrix interactions as therapeutic targets in the atherosclerosis of diabetes

Osman, Narin and Little, Peter J. (2014). Lipid: extracellular matrix interactions as therapeutic targets in the atherosclerosis of diabetes. In Alicia J. Jenkins, Peter P. Toth and Timothy J. Lyons (Ed.), Lipoproteins in diabetes mellitus (pp. 215-229) New York, United States: Springer. doi:10.1007/978-1-4614-7554-5_11


Author Osman, Narin
Little, Peter J.
Title of chapter Lipid: extracellular matrix interactions as therapeutic targets in the atherosclerosis of diabetes
Title of book Lipoproteins in diabetes mellitus
Place of Publication New York, United States
Publisher Springer
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4614-7554-5_11
Open Access Status Not yet assessed
Series Contemporary Diabetes
ISBN 9781461475538
9781461475545
ISSN 2197-7836
Editor Alicia J. Jenkins
Peter P. Toth
Timothy J. Lyons
Chapter number 11
Start page 215
End page 229
Total pages 15
Total chapters 23
Language eng
Abstract/Summary Most drugs for the treatment of diabetes and cardiovascular disease are targeted at measurable biochemical parameters which are identified risk factors. The targets include cholesterol, triglycerides, blood pressure, and glucose. The absolute target of all such therapies is the prevention of cardiovascular disease being mostly atherosclerosis and its major clinical sequelae of heart attacks and strokes. Cardiovascular disease remains the commonest cause of death in people with diabetes. The initiation of human atherosclerosis depends on extracellular matrix lipoprotein interactions, and this chapter reviews the current knowledge of matrix targets in the development of atherosclerosis associated with diabetes and the potential of matrix components as new therapeutic targets.
Keyword Vascular smooth-muscle
Pdgf-beta-receptor
Increases collagen content
Low-density lipoproteins
To-retention hypothesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: School of Pharmacy Publications
 
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